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Finally, a targeted CRISPRCas9 screen shows that epithelioids recapitulate mutant gene selection in aging human esophagus and identifies additional drivers of clonal expansion, resolving the genetic networks underpinning competitive fitness

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Indeed, although having the typical GST fold, none of the cysteine of the CPxC signature found in plant sequences is conserved in other organisms notably mammals, and there is no evidence for a cysteine involvement or for a requirement of GSH for their function

Figure 6 Endothelial cells exposed to inflammatory and metabolic stress upregulate cell adhesion molecules including ICAM-1, VCAM-1, and E-selectin

M.FriederJ.WuJ.et al (2012)