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Another was the discovery that tight junctional permeability is dynamic, altered by systemic inflammation and other factors such as enterotoxins and the volume of fluid absorption [23, 39], initially reported in the early 1980s in clinical studies of intestinal permeability in arthritis and celiac disease patients [37, 40]

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2532, 2023, doi: 10.4103/ijt.ijt_5_22

Fish oil fatty acid supplementation in active ulcerative colitis: A double-blind, placebo-controlled, crossover study

At nearly 5000 Da, it approaches the upper limit of what intranasal delivery can effectively handle