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Flohes objection points out that the rate constants for the spontaneous reactions of inter-conversion of thiol disulfides are negligibly small, with respect to those necessary to explain biological processes, and therefore the intervention of the enzymatic systems is of a crucial importance in determining the behavior of a biological system

The scientists found mixed results: While some studies showed the drugs offer neuroprotective benefits, other studies in the review raised the alarm that some medications in the drug class may increase depression and suicidal ideality

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Maes M, Bonifacio KL, Morelli NR, Vargas HO, Moreira EG, St Stoyanov D, et al

some patients reach therapeutic benefit at lower doses, while others advance to the full 2.4 mg maintenance dose