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Too high for too long may increase cancer risk

22: 1436-1446 Liu, X., Ouyang, JF., Rossello, F., Tan, JP., Davidson, KC., Valdes, DS., Schroder, J., Sun, YBY., Chen, J., Knaupp, AS., Sun, G., Chy, HS., Huang, Z., Pflueger, J., Firas, J., Tano, V., Buckberry, S., Paynter, JM., Larcombe, MR., Poppe, D.,Choo, XY., O'Brien, CM., Pastor, WA., Chen, D., Leicher, AL., Naeem, H., Tripathi, P., Das, PP., Grubman, A., Powell, DR., Laslett, AL., David, L., Nilsson, SK., Clark, AT., Lister, R., Nfzger, CM., Martelotto, LG., Rackham, OJL., Polo, JM (2020) Reprogramming roadmap reveals route to human induced trophoblast stem cells

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After 15-20 punctures, the stopper may not reseal properly, compromising the sterile environment