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The ongoing Phase 3 trials will provide longer-duration data to confirm this possibility

GLP-1 RA SmPCs (e.g., semaglutide) generally report no clinically relevant effect on overall drug exposure for most oral medicines, but individual monitoring remains prudent for narrow therapeutic index agents

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It is important to approach this discussion with realistic expectations, given that retatrutide does not currently hold a UK marketing authorisation and is therefore not available as a standard prescription medicine