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PT-141 is administered as a subcutaneous injection or nasal spray, taken 45 minutes to one hour before sexual activity, with doses typically ranging from 1mg to 2mg

Abbreviations DEG: Differentially expressed gene DHT: Dihydrotestosterone DSS: Dextran sulfate sodium E2: Estradiol ELISA: Enzyme-linked immunosorbent assay FBS: Fetal bovine serum FDR: False discovery rate GnRH: Gonadotropin-releasing hormone IACUC: Institutional Animal Care and Use Committee P4: Progesterone qPCR: Quantitative polymerase chain reaction SNP: Single nucleotide polymorphisms VO: Vaginal opening References Beldade P, Mateus ARA, Keller RA

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Companies with pipelines concentrated in biologics, cell therapies, and gene therapies have a structural advantage under the 13-year eligibility standard relative to small-molecule-heavy portfolios

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