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doi: 10.1086/500092 135

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[40] [41] Mechanism of action [edit] Tirzepatide has a greater affinity to GIP receptors than to GLP-1 receptors, and this dual agonist behavior has been shown to produce greater reductions of hyperglycemia compared to a selective GLP-1 receptor agonist

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Research indicates that GPER modulates AMPK activity through multiple mechanisms [57, 58]

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