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Administration Routes and Techniques Most GLP-1 agonists are administered via subcutaneous injection, meaning the medication is injected into the fatty tissue just under the skin

However, certain signs indicate a need for medical evaluation

Perhaps the patients liver enzymes spiked, or they experienced severe nausea or their insurer refused to cover further refills

In one study, for example, dysesthesia appeared in nearly 21 percent of retatrutide users versus less than 1 percent on placebo