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With the development of the first GIP/GLP-1 co-agonist, tirzepatide, there has been an exponential increase in the effectiveness of incretin-mimetic pharmacological therapy for weight control in obese patients with and without diabetes

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By promoting these neuroprotective pathways and improving insulin signaling, GLP-1based therapies offer substantial protection against T2DM-related neuronal damage in PD (Mller et al., 2019)