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In an extensive phase III clinical program including patients from across the disease spectrum, treatment with oral semaglutide resulted in effective glycemic control, reductions in body weight, and decreases in systolic blood pressure when used as monotherapy or in combination with other glucose-lowering therapies
Activation of AMPK in neurons also promotes mitochondrial biogenesis and oxidative glucose metabolism by increasing the expression of the master mitochondrial regulators, peroxisome proliferator-activated receptor gamma coactivator-1 ( PGC-1 ) and mitochondrial transcription factor A ( mtTFA ) [120]
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