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In Crohn's disease the article says this combination can affect symptoms unpredictably, with some patients reporting reduced inflammation and others increased cramping or diarrhea depending on where the disease sits and on baseline gut permeability

They are metabolised via the thiopurine S-methyltransferase (TPMT) enzyme, and polymorphisms in the gene encoding this enzyme can lead to variable enzyme activity and potential toxicity

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This research firmly establishes oxidative stress as a shared mechanistic basis for these conditions and underscores the critical need for targeted antioxidant therapies to protect cellular infrastructure