In the case of iron overload, the loss of SLC7A11 contributes to ferroptosis-related liver injury ( function, triggering ferroptosis in cancer cells derived from the liver, kidney, and lung ( in vivo , whereas SLC7A11 / embryonic fibroblasts underwent cell death in routine culture medium in vitro but could proliferate normally in the presence of 2-mercaptoethanol (2ME), N-acetyl cysteine (NAC), or vitamin E ( Inhibition of GSH synthesis triggers ferroptosis
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DHA@MIL-101 NRs self-disassembled in the acid microenvironment to dissociate Fe 3+ , achieving GSH consumption-mediated redox reaction and Fe 2+ -mediated Fenton reaction (Figure 5D)
Loren Pickart, this small protein fragment is found in human plasma, saliva, and urine, playing a crucial role in various biological processes
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