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To investigate the role of ROS and the mechanism of action of DPI in MNA cells, we employed a widely and commercially available mitochondria-targeted antioxidant, mitoquinone mesylate (MitoQ)
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Oral and topical glutathione are considered safer and effective options, while IV glutathione lacks strong evidence and carries risks
The microneedles' morphology helps avoid contact with the nerve endings or cutaneous blood vessels, therefore helping in pain-free administration and avoiding the potential transmission of blood-borne infection [175]
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