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Tirzepatide is a dual-acting medication that mimics two natural hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

In case of T2DM, both islets and peri-islet exocrine tissue of pancreas have an activated PSC

Tirzepatide produces impressive early weight loss in many patients, but roughly 30% experience a plateau within six months of starting treatment

If you, or someone you care for, is taking GLP-1s and you notice symptoms such as severe, persistent stomach pain that may radiate to the back and may be accompanied by nausea and vomiting, then we advise you speak to a healthcare professional and report it via our Yellow Card scheme. The Yellow Card Biobank, a collaboration between the MHRA and Genomics England, has recruited patients taking GLP-1s to investigate whether the risk of an inflamed pancreas may be influenced by an individuals genes

But how does it function