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While their glycemic, weight-lowering, and cardiovascular benefits are well established through randomized trials and meta-analyses, concerns remain regarding their safety and tolerability across diverse populations and clinical settings

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However, phentermine's effects are centered on hunger suppression through stimulation rather than on metabolic regulation or appetite hormone signaling

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There is a large market for weight loss medicationsaccording to the FDA, around 70% of Americans dealing with obesity or being overweight, many of whom also have a medical diagnosis contributing to their weight