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Serum immunoreactive-leptin concentrations in normal-weight and obese humans Metabolism: Volume 64, Issue 1, January 2015, Pages 24-34 Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism Leptin resistance: underlying mechanisms and diagnosis Biochem Mol Med doi: 10.1006/bmme.1996.0056

Its also important to note that binge eating is often a direct result of restrictive eating

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Adipose tissue can store toxins AND, toxins can increase the growth of adipose tissue

Some randomized controlled trials report modest improvements in pain and function, particularly in patients with mild-to-moderate knee OA, while others show minimal benefit compared to placebo (Chavda et al., 2022