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In the discussion section of the Harvard paper, the authors wrote that GLP-1 RA-induced enhanced sympathetic nervous system activity might influence optic nerve head perfusion and potentially increase the risk of NAION, but, again, Rizzo pointed out that this study was only observational and that potential causative mechanisms need a different kind of investigation

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Our approachthe Blue Horizon Methodprioritizes clinical responsibility: always consult your GP first to rule out serious conditions, use structured tracking to understand your symptoms, and consider targeted private testing only when you need a clearer "map" for professional medical conversations

Simon analyze commercial insurance claims for approximately 537,000 patients who initiated GLP-1 treatment between 2017 and 2022