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The STEP clinical trials of semaglutide showed average weight reductions of roughly 12 to 15 percent of starting body weight over 68 weeks, while the SURMOUNT trials of tirzepatide showed slightly greater average weight loss, with reductions of roughly 18 to 22 percent of starting body weight at the highest doses

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This 39-amino-acid molecule incorporates structural elements derived from both native GIP and GLP-1, with targeted amino acid substitutions that optimize receptor binding and functional activity

3b, Supplementary Fig

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