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Our recent work used a 3Tg-AD model to show that dysregulated expression of monoacylglycerol lipase (Mgll) caused by the impaired atypical protein kinase C (aPKC) mediated CREB binding protein (CBP) phosphorylation in AD can be used as a marker to guide metformin-targeted therapy (reactivating the impaired aPKC-CBP pathway) to correct perturbed neurogenesis and spatial memory in AD (Syal et al., 2020)

Before this, most clinical trials were performed in [whites] or maybe Americans

Introduction Glutathione is the body's most powerful antioxidant, playing a central role in detoxification, immune function, and cellular health

Lifestyle factors compound the challenge

Blood samples collection and analytical procedures Maternal blood, at inclusion and delivery, and arterial and venous umbilical cord blood were collected