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In fact, nearly one third of all the NTS GLP-1-producing neurons send ascending fibers to the VTA and the NAc (core and shell regions) (Dossat et al., Figure 1 GLP-1R-driven activation of the mesolimbic neurons On the basis of immediate early gene expression analysis it seems that GLP-1 or its analogs can increase neuronal activity in the mesolimbic system

Current evidence remains limited, with most clinical experience coming from case reports and small observational studies rather than large randomized trials

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