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The glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and now next-generation multi-agonists that include GLP-1 activity, are producing average weight reductions far larger than previously expected from drugs, reshaping clinical practice and how clinicians and patients think about obesity treatment

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Rare Variants in PPARG With Decreased Activity in Adipocyte Differentiation are Associated With Increased Risk of Type 2 Diabetes