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Cardiac differentiation was performed as we previously described (Supplementary Figure 1A) (Supplementary Figure 1B) and had high purity, as indicated by flow cytometry (Supplementary Figure 1C)

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Lower doses of 10 ng/kg produce comparable effects via signalling cascades

400 In the last decades, researchers have showed that IR is an early metabolic alteration in CKD, because IR plays a primary role in metabolic syndromes characterized by abdominal obesity, high fasting glucose levels, hypertriglyceridemia, depressed serum HDL-C, and high blood pressure, that are commonly observed in CKD patients