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MIC-B12 has a documented safety profile in the clinical literature, though common side effects, warnings, and contraindications vary by formulation

Responses to B12 can vary significantly due to individual factors like genetic differences in B12 metabolism and conditions like pernicious anaemia

J Crohns Colitis 14:422 Tran CD, Howarth GS, Coyle P, Philcox JC, Rofe AM, Butler RN (2003) Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine