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In particular, ZAG decreases fatty acid synthase (FAS), acetyl-coenzyme A carboxylase 1 (ACC1), acyl-coenzyme A: diacylglycerol transferase 1 (DGAT1), and increases hormone-sensitive lipase (HSL) activity, resulting in increased lipolysis and decreased lipogenesis in murine adipose tissue [89]

Since neurons require high energy supplied by healthy mitochondria to get excited, the brain is very sensitive to dyshomeostasis of mitochondrial redox-sensitive signaling (57)

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Researchers investigate receptor binding, intracellular signaling, and metabolic pathway responses associated with this concurrent triple activation, comparing it with single- and dual-agonist profiles in controlled laboratory settings [2]