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J.BkenkampA.ChristenssonA.DubourgL.EriksenB

Participants also recorded reductions in waist circumference (average 7.1cm loss on 6mg, 8.2cm on 12mg, 10cm on 36mg, compared with 3.1cm loss on placebo), blood pressure (estimated -4.2 and -1mm HG difference between placebo and orforglipron in systolic and diatolic blood pressure, respectively) and cholesterol (-2.1% difference between placebo and orforglipron)

In virt di tali caratteristiche, essi mostrano un effetto pi marcato sul rallentamento dello svuotamento gastrico, che si traduce in una maggiore riduzione dellincremento glicemico post-prandiale, mentre sono meno efficaci sul controllo della glicemia a digiuno, della secrezione basale di insulina e sul mantenimento di valori stabili di emoglobina glicata (HbA1c) [1214]

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Once-weekly semaglutide led GLP-1 options for weight and metabolic improvements in psychiatric populations, but researchers say stronger head-to-head trials are still needed before firm clinical rankings can be made