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AMPT exerts its inhibitory actions on tyrosine hydroxylase, which will lead to a severe impairment in the endogenous production of dopamine [25, 31]

Increased dysbiosis, impaired intestinal barrier, bacterial translocation and pro-inflammatory response play an important role in the development of chronic liver disease

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A potential unifying feature that enhances susceptibility among those with each of these conditions is an elevation in systemic inflammation, which leads to a greater viral load with the potential for a cytokine storm and increased mortality 3