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Although GLP-1 RAs have been shown to promote greater weight loss than lifestyle intervention in patients without psychiatric disease, the efficacy, safety, and overall applicability of this strategy for patients with psychiatric disease was uncertain

Many commenters expressed their need for additional information so that interested parties would be able to accurately replicate Addendum J

Diabetologia 1994 37 1163-1166 Perea A, Vinambres C, Clemente F, Villanueva-Penacarrillo ML & Valverde I

A: Growing preclinical and clinical trials confirm GLP-1 agonists possess multi-organ protective effects beyond metabolic regulation, expanding their therapeutic boundary steadily