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If patients do not tolerate a dose during dose escalation, consider delaying dose escalation for 4 weeks The maintenance dosages of Wegovy for weight reduction in adults are 1.7 mg, 2.4 mg (recommended), or 7.2 mg (when additional weight reduction is clinically indicated) injected subcutaneously once weekly

T lymphocytes in individuals suffering from chronic obstructive pulmonary disease (COPD) have been found to be immunodeficient, with an increased functional exhaustion of T cells that express PD-1, a negative co-stimulatory molecule linked to impaired immune responses [166]

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Li Qian, Wenjun Wang, Yan Zhou, Jianxin Ma

Cytokine quantification Cytokine concentrations in culture supernatants and BALF samples were quantified using either LEGENDplex Mouse Th Panel or LEGENDplex Human Th2 Panel (BioLegend) per the manufacturers instructions and described previously (47, 71, 73, 75, 76)