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One theory is that its effects may have something to do with the drugs ability to induce the feeling of satiation

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A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-1)

Antibodies also exist, among others, to megalin (the thyroid cell Tg receptor) (182), to the thyroidal iodide symporter (183), and to components of eye muscle and fibroblasts in patients with thyroid eye disease (184) (Table 2)

2 The FDAs official statement builds on Commissioner Marty Makarys X post from February 5 th , saying that the agency would move against copycat drugs marketed as comparable to approved therapies, warning that regulators will take swift action against companies mass-marketing illegal copycat drugs, claiming they are similar to FDA-approved products