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GIP activation appears to act synergistically with GLP-1 receptor activation, enabling greater weight reduction than GLP-1 receptor agonism alone

[10] [11] More recently, the SELECT trial showed that Wegovy significantly reduced the risk of major adverse cardiovascular events in adults with established cardiovascular disease and overweight or obesity without diabetes, leading to an FDA-approved cardiovascular risk reduction indication

Immune system recalibration Immunosenescence, the gradual deterioration of immune function with age, is one of the most significant contributors to age-related disease risk

Dr Norman is not advocating for the use of these drugs off-label, and notes that any person taking these drugs should be under the care of a licensed professional who is expert in their use and potential side effects.

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