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If bleeding has been frequent or prolonged, checking for iron deficiency anaemia (with blood tests for full blood count and ferritin) may be appropriate, with iron supplementation if indicated

However, colonoscopy remains the gold standard for comprehensive evaluation, particularly in patients 45 and older or those with alarm features

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The post names patients with severe gastrointestinal intolerance, a medullary thyroid cancer history, pancreatitis risk, or dehydration concerns as potentially requiring a cap below the top tier

Wnk1 : Wnk1 is a Ser/Thr protein kinase and mutations in the nervous system-specific HSN2 exon of Wnk1 cause hereditary sensory neuropathy type II [54]