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FIGURE 1 HMP ) pathway is favored because EMP enzymes are sequestered to AE1, freeing up shared substrate and generating NADPH that provides the reducing equivalents necessary to power antioxidant systems in the face of high O 2 flux

Receptor endocytosis, an intermediate step toward downregulation, is also necessary for resensitization via dephosphorylation and recycling 11, thus, totally inhibiting endocytosis will likely result in reduced signaling as surface receptors become desensitized via -arrestin recruitment

2005), but there is less evidence of their occurrence in human urine (Raml et al

It may help provide context for provider conversations about treatment suitability

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