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Fatigue represents one of the most commonly reported side effects during semaglutide use, particularly in the first 4 to 8 weeks of treatment

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The primary mechanisms by which genetic variants contribute to NAFLD include altered lipid metabolismleading to excessive hepatic fat accumulationand heightened pro-inflammatory signalling, which drives hepatic inflammation, fibrosis, and the progression to non-alcoholic steatohepatitis (NASH) [110, 111]