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These findings suggest that targeting the IGF system may offer a promising strategy for CRC treatment, either by directly inhibiting IGF-1R or by modulating the activity of IGFBPs to restore balance and inhibit tumor progression [5, 8]

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Plans are presumably aware that the data supportive of Wegovys supplemental indication imply an absolute risk reduction of 1.5% of significant cardiovascular events among clinical trial participants, which is relatively small

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doi: 10.1152/ajpgi.00024.2008

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10.1038/ncomms14108 46 SunK.LiuH.SongA.ManaloJ

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