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These effects are generally mild to moderate and tend to improve within 24 weeks as the body adjusts to the medication

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Tambin inhibe la produccin de citoquinas proinflamatorias (TNF-, IL-6, TGF- en exceso) mientras estimula las citoquinas antiinflamatorias (IL-10)

The most significant reaction of mevalonate pathway, which represents the rate-limiting reaction, is catalyzed by 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR