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These data demonstrate that metformin, significantly radiosensitises radiosensitive HCT116 cells and radioresistant SW837 cancer cells at a clinically-relevant dose of 1.8 Gy

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Abbreviations BBB: Blood brain barrier BSP: Bisulfite sequencing PCR CNS: Central nervous system COVID-19: Coronavirus disease 2019 CpG: Cytosine-phosphate-guanine DML: Differentially methylated locus HCY: Homocysteine MS: Multiple sclerosis PET-CT: Positron emission tomography - computed tomography ROCF: Rey-Osterrieth complex figure ROS: Reactive oxygen species RT-qPCR: Real time quantitative polymerase chain reaction SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 TF: Transcription factor TFBS: Transcription factor binding site VCD: Visuoconstructive deficiency WHO: World Health Organization References Centers for Disease Control and Prevention (CDC)

Sequence characteristics and domain organization of cysteinyl GSTs From the phylogenetic tree and the amino acid sequence alignments, there are key sequence differences that allow differentiation of each class