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Over a period of 6 months, patients lost an average of 12.8 kg, 11.3 kg, and 6.7 kg on the 1 mg, 0.5 mg, and 0.25 mg doses, respectively, as compared to a 2.2 kg weight loss in the placebo group [76]

They often start with a higher dose, then get smaller doses based on how they do

Many commenters indicated that hospitals would need additional time to review new guidance, develop plans for updating the files, coordinate with vendors, encode the data, validate for accuracy, and refresh and post the files

Human pharmacokinetics are not established