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It should not be used by people who are pregnant or breastfeeding, those who have liver, heart, or kidney disease (especially people with a history of stomach or intestinal ulcers), or by people with psychiatric conditions
As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19
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Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis
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