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Previous studies have revealed that alterations in the mechanisms directing tumor development may initiate or interfere with immune responses in the TME, leading to either immune resistance or dysfunction, and eventually resulting in the tumor's avoidance of the immune system

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A 50% increased risk to develop breast cancer in nurses exposed to rotating shift work has been documented (74)

For patients who have a clear clinical goal and a protocol that matches it, committing to three cycles upfront is both the more economical and the more clinically sound decision

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