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Lastly, genetic manipulation of antioxidant genes, such as Sod1 , Gpx 1 and Cat , in animal models alters susceptibility to alcohol-induced liver injury 28,29,30

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A major extracellular enzyme, GPX3, is also found in the cytoplasm and plasma membranes of the mammalian kidney, epididymis, heart, lung, liver, brain, adipose tissue, mammary gland, and gastrointestinal tract (Nirgude and Choudhary, 2021)

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