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GLP-1 agonists work through GLP-1 receptors affecting appetite and glucose metabolism

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Where it works: Adipose tissue (fat cells): Reduces inflammation and may improve fat metabolism Pancreas: Works alongside GLP-1 to enhance insulin secretion Brain: May contribute to appetite regulation (research ongoing) Weight loss contribution: When GIP is added to GLP-1 (as in tirzepatide), weight loss increases from ~15% to ~22%