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Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation

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Oncogene 24 , 17381748 (2005)

Understanding exactly what IGF-1 LR3 does, how it differs from other IGF variants, and how to use it safely requires diving deep into the science