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While extensively studied in preclinical and small clinical settings, GHK-Cu lacks FDA approval as a pharmaceutical agent and is primarily available in cosmetic formulations for topical use

placebo at 6 months] 1.3, 95%CI 0.891.88) in 300 people with HF, with and without type 2 diabetes and with recent decompensation (Margulies et al., 2016)

Naturally used to encapsulate substances such as proteins and nucleic acids and transport them to target cells, this property of exosomes has been exploited to be used as a drug delivery system, with advantages such as improved biocompatibility and stability, improved targeting, and reduced toxicity

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Methods This study conducted a comprehensive review of randomized clinical trials evaluating the effects of GLP-1 RAs and SGLT2is in women with PCOS