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Primary Functions of GLP-2 Intestinal Growth and Repair Promotes growth of the intestinal lining (mucosa) Increases the height of intestinal villi (finger-like projections that absorb nutrients) Stimulates crypt cell proliferation Enhances overall intestinal surface area Nutrient Absorption Improves the absorption of nutrients from food Increases blood flow to the intestines Enhances nutrient uptake capacity Supports optimal digestive function Gut Barrier Function Strengthens the intestinal barrier Reduces intestinal permeability (leaky gut) Protects against harmful substances entering the bloodstream Maintains gut integrity Anti-Inflammatory Effects Reduces inflammation in the intestinal tract Promotes healing of damaged tissue Supports immune function in the gut May help with inflammatory bowel conditions Slows Gastric Emptying Like GLP-1, GLP-2 also slows stomach emptying Allows more time for nutrient absorption Contributes to feelings of satiety Why People Use GLP-2 Short Bowel Syndrome: GLP-2 analogs (like teduglutide) are FDA-approved for treating short bowel syndrome, a condition where part of the intestine has been removed

The proposed resolution lies in remodeling

However, with IBD-current biologic therapies, all these mean some patients primary non-responders, experience a loss of response, intolerance or side effects, defining the urgent unmet need for novel treatments (13, 14)

(Updated August 17, 2023)