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The idea that a leaky gut can cause problems outside the intestine relies on the hypothesis that microbial products in the intestine are able to escape the gut and elicit an inflammatory reaction wherever they may end up. Chung, Patel and colleagues took a two-pronged approach in their study: a meta-analysis of the existing literature to compare the rates of increased intestinal permeability in patients with or without NAFLD, and in vitro and in vivo experiments to explore the underlying mechanisms that contribute to this change in intestinal permeability

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