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Safety Considerations and Who Should Avoid GLP-1 GLP-1 is not appropriate for everyone

However, the oral GLP-1 product, Rybelsus, has low bioavailability and requires cumbersome daily administration, which reduces its convenience

First, fat depot coverage

Similar to patients with diabetes mellitus, those with obesity taking GLP-1 RAs have a significant reduction in MACE, all-cause death, myocardial infarction, and revascularisation, without significant differences in rates of cardiovascular death or stroke