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2 MASLD is primarily characterized by abnormal lipid accumulation in hepatocytes, typically presenting as simple steatosis

Thus, in the most metabolically active tissues such as renal cells, hepatocytes, endocrine cells, endothelial cells, and neurons, low GSH levels should be expected to be directly correlated with worse cellular function and early cell death

In a parallel-arm, open-label human study, twelve healthy subjects ( n 6 per group) received a single oral dose of either LipoDuo or plain glutathione (1 g), and plasma glutathione levels were monitored over 24 h using LC-MS/MS