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The conversion of ribonucleotides to deoxyribonucleotides (through the action of ribonucleotide reductase) requires NADPH as the electron source, therefore, any rapidly proliferating cell needs large quantities of NADPH

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Lipid metabolic pathways confer the immunosuppressive function of myeloid-derived suppressor cells in tumor

[PMID: 33026101 DOI: 10.1111/eci.13423] [DOI] [PMC free article] [PubMed] [Google Scholar] 2.Gavriatopoulou M, Korompoki E, Fotiou D, Ntanasis-Stathopoulos I, Psaltopoulou T, Kastritis E, Terpos E, Dimopoulos MA