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The deficiency is probably more common in those following vegan and strict vegetarian diets for at least some years

Effectiveness depends on multiple factors beyond dose alone, including dietary habits, physical activity, individual metabolism, and how well you tolerate the medication

Most magnesium forms don't directly interfere with semaglutide absorption, but separating them ensures each substance works optimally in your body

Clinicians should monitor for changes in drug effectiveness or unexpected side effects

doi: 10.3389/fphar.2025.1618079 Received 28 April 2025 Accepted 08 July 2025 Published 24 July 2025 Volume 16 - 2025 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Yang Yang, Chinese PLA General Hospital, China Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Updates Copyright 2025 Xie, Yang, Tian and Chen