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Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk

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Best Form of B12: Comparing Effectiveness and Clinical Use Choosing the best form of B12 depends on your individual health needs, absorption capacity, and whether you require prevention or treatment of deficiency